Focal Nodular Hyperplasia of Liver

Focal Nodular Hyperplasia (FNH) of the liver is a common non-cancerous growth of the liver.  Understanding its nature, causes, symptoms, and most importantly, its diagnosis through imaging techniques is crucial for effective management. This article will discuss FNH and the role imaging plays in its identification and diagnosis.

What is Focal Nodular Hyperplasia (FNH)?

FNH is a benign liver tumor characterized by an overgrowth of normal cells and blood vessels. It’s usually asymptomatic and is often incidentally discovered during routine imaging studies or examinations for other conditions. While the exact cause of FNH isn’t entirely clear, it is believed that abnormal blood vessel development might contribute to its formation.

Imaging Techniques for Diagnosing FNH:

  1. Ultrasound (US) Imaging:
    • Utilizes sound waves to create images of the liver.
    • Helps identify FNH by its specific appearance—typically a well-defined, solid mass with characteristic internal structures.
  2. Computed Tomography (CT) Scan:
    • Provides detailed cross-sectional images of the liver.
    • FNH appears as a well-circumscribed lesion with a central scar, often known as a “spoke-wheel” appearance due to its characteristic central stellate scar.
  3. Magnetic Resonance Imaging (MRI):
    • Uses powerful magnets and radio waves to generate detailed images.
    • Highly effective in distinguishing FNH from other liver lesions due to its specific enhancement patterns with contrast agents.
  4. Contrast-Enhanced Ultrasound (CEUS):
    • Involves the use of contrast agents to enhance ultrasound images.
    • Aids in differentiating FNH from other liver lesions, displaying a characteristic rapid enhancement during the arterial phase.

Key Imaging Findings of FNH:

  • Well-circumscribed, solitary lesion.
  • Central stellate scar (T1-hypointense, T2-hyperintense on MRI).
  • “Spoke-wheel” appearance on CT scan due to the fibrous septa.
  • Rapid arterial enhancement

Differential Diagnosis:

It’s essential to distinguish FNH from other liver lesions to determine appropriate management. Imaging findings that help differentiate FNH from similar conditions include:

  • Hepatocellular Adenoma: Lacks a central scar and has a more heterogeneous enhancement pattern.
  • Hepatocellular Carcinoma: Often presents with arterial hypervascularity and washout in the venous phase.
  • Hemangioma: Typically shows peripheral nodular enhancement with centripetal fill-in on imaging studies.


Imaging techniques play a fundamental role in diagnosing Focal Nodular Hyperplasia of the liver. Understanding the characteristic appearance of FNH on ultrasound, CT scans, MRI, and contrast-enhanced imaging is crucial for accurate identification and differentiation from other liver lesions.

Early and precise diagnosis through these imaging modalities enables proper management and appropriate interventions, ensuring better patient outcomes and quality of life. If you suspect any liver abnormalities or experience concerning symptoms, consult a healthcare professional for timely evaluation and management.

Remember, while imaging aids in diagnosis, the final diagnosis and treatment plan should be determined by a healthcare provider after a thorough evaluation of all clinical and imaging findings.


Disclaimer: The content of this website is provided for general informational purposes only and is not intended as, nor should it be considered a substitute for, professional medical advice. Do not use the information on this website for diagnosing or treating any medical or health condition. If you have or suspect you have a medical problem, promptly contact your professional healthcare provider.

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